Julian West
7 months ago

NLRP3 - Aging and Chronic Inflammation (beyond Senescent Cells)

NLRP3 - Aging and Chronic Inflammation (beyond Senescent Cells)

Every poignant dramatic story has an arch-villain. The aging process has many! A well-known one is chronic inflammation - sometimes referred to as "Inflammaging" (the vicious cycle between inflammation and aging.) An often-discussed source of chronic inflammation are senescent cells - but they aren't the only one. The N...
LongevityCell BiologyPharmacologyInflammasomes IL-1β IL-18 Life123 CANTOS BioAge Labs Inflammation Inflammaging NLRP3 Pyroptosis Healthspan
Julian West
9 months ago

Removing Toxic Biomolecules that Accumulate with Age

Removing Toxic Biomolecules that Accumulate with Age

Something I love about scientific conferences is being exposed to less widely known - but potentially very important - avenues of research. Case in point: the accumulation of a toxic biomolecule, an oxidized form of cholesterol (7-ketocholesterol : https://pubchem.ncbi.nlm.nih.gov/compound/7-Ketocholesterol ), believed to ...
LongevityCell BiologyPharmacologyCholesterol Atherosclerosis Cyclodextrins 7-ketocholesterol Cyclarity Therapeutics Matthew O'Connor Conferences Ending Age-Related Diseases 2022 UDP-003 Candymer software Healthspan
Sam
over 1 year ago
Method

Materials and methods